Observe Intently (two)pentobarbital will lessen the extent or impact of suvorexant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Strong CYP3A4 inducers could decrease suvorexant efficacy; if elevated suvorexant dose demanded, will not exceed 20 mg/working dayKeep an eye on Carefully (1)pentobarbital will raise