Observe Intently (two)pentobarbital will lessen the extent or impact of suvorexant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Strong CYP3A4 inducers could decrease suvorexant efficacy; if elevated suvorexant dose demanded, will not exceed 20 mg/working day
Keep an eye on Carefully (1)pentobarbital will raise the amount or impact of clopidogrel by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will lessen the level or effect of alfuzosin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unknown.
pentobarbital will lessen the extent or influence of lumefantrine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with solid CYP3A4 inducers can result in reduced serum concentrations and loss of antimalarial efficacy
pentobarbital will lessen the extent or result of isradipine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unknown.
Monitor Intently (one)pentobarbital will reduce the level or impact of mifepristone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. CYP3A4 inducers have not been studied, coadministration not recommended by maker
pentobarbital will lower the level or effect of pimozide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Mysterious.
pentobarbital will lessen the extent or impact of pazopanib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
pentobarbital will here decrease the level or effect of colchicine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
pentobarbital will minimize the level or influence of etoposide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
pentobarbital will lower the extent or impact of tamoxifen by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
Remark: Barbiturates may possibly boost adverse effects, which includes respiratory depression, made by harmful doses of TCAs. With therapeutic doses of TCAs, barbiturates enhance metabolism and reduce blood concentrations of TCAs.
pentobarbital will lower the level or outcome of lefamulin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Stay away from coadministration of lefamulin with powerful or moderate CYP3A inducers Unless of course the reward outweighs risks. Check for diminished efficacy.
pentobarbital will lessen the level or impact of ziprasidone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unknown.